Source: http://www.sciencedaily.com/releases/2013/07/130710141901.htm
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Source: http://www.sciencedaily.com/releases/2013/07/130710141901.htm
norovirus Eclampsia Kendrick Lamar JJ Abrams New Orleans Pelicans chris brown hillary clinton
Bladder cancer kills more than 15,000 Americans each year, and is expected to cause about 73,000 new cancer cases in 2013.
Researchers report they have developed a "scent device" called the Odoreader that they hope may prove to be a reliable way to sniff out cancer in patients' urine before it becomes a serious problem.
(Credit: University of Liverpool)More than 500,000 bladder cancer survivors live in the U.S., according to the American Cancer Society. Nine out of 10 of those affected are 55 years of age or older.
"It is a disease that, if caught early, can be treated effectively, but unfortunately we do not have any early screening methods other than diagnosis through urine tests at the stage when it starts to become a problem," study researcher Dr. Chris Probert, a professor at the University of Liverpool's Institute of Translational Medicine in the U.K., said in a news release.
Most cases of bladder cancer begin in cells that line the inside of the bladder, the Mayo Clinic notes. It can cause symptoms like blood in the urine, frequent or painful urination, and back and pelvic pain.
The BRCA biomarker is sometimes used to screen for risk of breast and ovarian cancers. But, currently there are aren't reliable biomarkers -- or measurable molecular signs of a disease -- that can be used to screen for bladder cancer, according to the study authors.
That's where the Odoreader could come in.
Previous research suggests dogs can successfully sniff out bladder cancer, as 60 Minutes reported in 2005. Dogs are now being utilized by some health care facilities to try and spot other types of cancers, including ovarian types.
The researchers speculated the dogs were picking up the scents of certain gasses emitted by urine. They built a device that contains a sensor that can analyze the gases and create a readout of the chemicals found in the urine within 30 minutes.
They tested it on 24 samples taken from patients with confirmed cases of bladder cancer and 74 samples from patients who had urological symptoms, but no confirmed cancer. The Odoreader correctly picked 100 percent of the cancer patients.
The study was published July 8 in PLoS One.
Prober added that bladder cancer can be expensive to treat because of multiple scopes required to track the cancer's development, so the new test may dramatically cut costs.
Other ways to diagnose bladder cancer include a cytoscope tube with a lens inserted through the urethra under local anesthesia, imaging tests of the urinary tract, a biopsy or a urine test to look for presence of cancer cells, according to the Mayo Clinic.
"The researchers say that the test would be around 96% accurate in practice and their findings are only based on a relatively small number of samples, taken only from men," Dr. Sarah Hazell, senior science communications officer at the nonprofit Cancer Research U.K., said to the BBC.
She added while the work is promising, there's still a ways to go.
"It is another promising step towards detecting bladder cancer from urine samples, something that would ultimately provide a less invasive means of diagnosing the disease," she commented.
This story originally appeared as "Scent device ODOREADER may sniff out bladder cancer" on CBSNews.com.
Source: http://feedproxy.google.com/~r/cnet/JhqR/~3/WNXCP1rdBzk/
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Devin Coldewey NBC News
6 hours ago
Jasper Van Loenen
The drone kit applied to a keyboard.
If you want a drone but you feel all the existing options aren't quite your style, you may want to give a "Drone It Yourself" kit a try. Clip the rotors and power supply to your phone or book or cardboard box or piece of toast, and watch it take flight!
Everything required appears in that stylish case below: four rotors, a power supply and flight control unit. The idea is to just unpack it, assemble and attach to the lucky item that will be your new drone body. It won't support anything that weighs more than a couple of pounds, though: Drones have to be light to get off the ground, so your dreams of flying toasters may go unfulfilled for now.
Jasper Van Loenen
The full kit, with 3-D printed pieces and motorized parts.
It's not for sale just yet, but the kit is really nothing more than 3-D printed parts that attach with clamps. And the creator, Jasper Van Loenen, has made the printer files available, so you can make them yourself.
Some expertise is required, of course. Your paperback or toy car may not handle as well as an item that was actually meant to fly. But it could be a fun project for the savvy RC and 3-D printing fans out there to try on a summer afternoon.
Devin Coldewey is a contributing writer for NBC News Digital. His personal website is coldewey.cc.
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SOUTH SAN FRANCISCO, Calif. (AP) ? Asiana Airlines Flight 214 was 500 feet up and about a half-minute from San Francisco International Airport when its speed dropped below the threshold for a safe landing speed. It continued slowing until just about 8 seconds before touch down when pilots recognized the need for more speed and throttled up.
But it already was too late. By the time the engines started adding speed, the hulking Boeing 777 was barely above San Francisco Bay and the plane clipped the seawall at the end of the runway, slammed down and spun, then caught fire. Incredibly, only two of the 307 people on board died, and most of the survivors suffered little or no injuries.
The head of the National Transportation Safety Board on Monday revealed additional details about the final seconds before Saturday's crash but what remained unknown was why the pilots didn't react sooner.
Some of those answers are expected to come Tuesday, after details emerge from U.S. and Korean joint interviews with the pilots that began Monday.
Choi Jeong-ho, a senior official for South Korea's Ministry of Land, Infrastructure and Transport, told reporters in a briefing Tuesday in South Korea that investigators from both countries quizzed two of the four Asiana pilots, Lee Gang-guk and Lee Jeong-min, on Monday, and they planned to quiz the two other pilots and air controllers Tuesday.
Choi said recorded conversation between the pilots and air controllers at the San Francisco airport would be investigated, too.
"I think this accident is going to go down as a textbook case study on what they call Cockpit Resource Managements, which is a fancy way of saying how the pilots talk to each other and identify solutions," said former NTSB managing director Peter Goelz.
He said it's very helpful, and not all that common after a major crash, to have pilots to interview.
"It's always good to have survivors," he said.
As for the interviews, "The reality is this is not going to be an interrogation," he said. "The NTSB will ask them to tell us in your own words what was going on. The investigators will have some advantage, they'll have some information from voice recorder. But it's not a cross examination, it's an effort to understand what the pilot remembers and what he remembers saying and doing."
He said there is a possibility a license could be revoked, or fines or penalties issued.
"The FAA will take a look at this going down the road and see if there were any egregious violations," he said.
The challenge for authorities this week is to discover what decisions were made in the cockpit of the giant jet, where an experienced pilot was learning his way around a new aircraft and fellow pilots were supposed to be monitoring his actions. Questions include whether all four pilots were in the cockpit, as expected, or just the trainee and his trainer, both experienced pilots.
In addition, authorities were reviewing the initial rescue efforts after fire officials acknowledged that one of their trucks may have run over one of the two Chinese teenagers killed in the crash. The students, Wang Linjia and Ye Mengyuan, were part of a larger group headed for a Christian summer camp with dozens of classmates.
National Transportation Safety Board Chairman Deborah Hersman said investigators reviewed flight data and watched airport surveillance video to determine whether an emergency vehicle ran over one of students. But they have not reached any firm conclusions. A county coroner said he would need at least two weeks to rule in the matter.
The teens had been seated in the rear of the aircraft, where many of the most seriously injured passengers were seated, Hersman said. Their bodies were found on the tarmac.
The investigators found traces of fire on the left side of the exterior parts of the plane's right engine, according to a statement from South Korea's Ministry of Land, Infrastructure and Transport. They also detected a skid mark at the runway, it said.
The NTSB also said part of the jet's tail section was found in San Francisco Bay, and debris from the seawall several hundred feet down the runway, indicating the plane hit the seawall on its approach.
Two other South Korean investigators ? one from the government and one from Asiana ? left for Washington to take part in an analysis of the plane's black box, and they are to arrive in Washington 11:20 a.m. local time Tuesday, the statement said.
The airline acknowledged Monday in Seoul that the pilot at the controls had little experience flying that type of plane and was landing one for the first time at that airport.
Asiana spokeswoman Lee Hyomin said pilot Lee Gang-guk had logged nearly 10,000 hours operating other planes but had only 43 hours in the 777, a plane she said he still was getting used to flying.
It was unclear whether the other two pilots were in the cockpit, which seats four. But that would be standard procedure at the end of a long international flight.
More than 180 people aboard the plane went to hospitals with injuries. But remarkably, more than a third didn't even require hospitalization.
The passengers included 141 Chinese, 77 South Koreans, 64 Americans, three Canadians, three Indians, one Japanese, one Vietnamese and one person from France.
South Korea officials said 39 people remained hospitalized in seven different hospitals in San Francisco. South Korean officials and 62 workers from Asiana and 30 from United Airlines are assisting the injured passengers and their family members.
The flight originated in Shanghai, China, and stopped over in Seoul, South Korea, before making the nearly 11-hour trip to San Francisco.
___
Associated Press writers Jason Dearen, Terry Collins, Paul Elias, Lisa Leff and Sudhin Thanawala in San Francisco, Joan Lowy in Washington, Gillian Wong and Didi Tang in Beijing, and Hyung-jin Kim in Seoul contributed to this report.
Source: http://news.yahoo.com/pilot-interviews-key-answers-sfo-crash-084528576.html
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Sci. Signal., 2 July 2013
Vol. 6, Issue 282, p. ra53
[DOI: 10.1126/scisignal.2003926]
Suchita Lal1, Anna Allan1, Danijela Markovic2, Rosemary Walker3, James Macartney1, Nick Europe-Finner4, Alison Tyson-Capper4, and Dimitris K. Grammatopoulos1*
1 Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
2 Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
3 Department of Cancer Studies & Molecular Medicine, Clinical Sciences Building, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK.
4 Reproductive and Vascular Biology Group, Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Abstract: Hormonal stress response is associated with the pathogenesis of disease, including cancer. The role of the stress hormone CRH (corticotropin-releasing hormone) in breast cancer is complex, and its abundance and biological activity may be modulated by estrogen. In the estrogen receptor?positive (ER+) malignant mammary epithelial cell line MCF7, CRH activated numerous kinases and downstream effectors, at least some of which were mediated by the CRH receptor type 1 (CRH-R1). CRH also increased the transcription of many genes that encode effectors, transcriptional targets, or regulators associated with estrogen signaling. Estrogen increased the abundance of the mRNA encoding CRH-R2 and an alternative splice variant encoding CRH-R1 in which exon 12 was deleted [CRH-R1(12)]. Estrogen inhibited the expression SRSF6, which encodes serine/arginine-rich splicing factor 55 (SRp55). An increase in CRH-R1(12), in response to either estrogen or SRp55 knockdown, dampened the cellular response to CRH and prevented its inhibitory effects on cell invasion. SRp55 knockdown also induced additional splicing events within exons 9 to 12 of CRH-R1, whereas overexpression of SRp55 prevented estrogen-induced generation of CRH-R1(12). ER+ breast tumors had increased CRH-R2 and CRH-R1(12) mRNA abundance, which was associated with decreased abundance of the mRNA encoding SRp55, compared with the amounts in ER? tumors, suggesting that estrogen contributes to the pathophysiology of ER+ breast cancer by altering CRH receptor diversity and disrupting CRH-mediated signaling.
* Corresponding author. E-mail: d.grammatopoulos{at}warwick.ac.uk
Citation: S. Lal, A. Allan, D. Markovic, R. Walker, J. Macartney, N. Europe-Finner, A. Tyson-Capper, D. K. Grammatopoulos, Estrogen Alters the Splicing of Type 1 Corticotropin-Releasing Hormone Receptor in Breast Cancer Cells. Sci. Signal. 6, ra53 (2013).
Source: http://stke.sciencemag.org/cgi/content/abstract/6/282/ra53?rss=1
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/jsHpnA4rNJQ/130707162956.htm
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PARIS--A French court Monday acquitted energy giant Total SA (TOT) and its chief executive of corruption and embezzlement in a case arising from the United Nations-sponsored oil-for-food program in Iraq.
The Paris court also dismissed corruption charges against the 18 other defendants in the case, including a former minister and a former French ambassador.
Total and its chairman and CEO, Christophe de Margerie, faced accusations of having paid kickbacks to Iraqi civil servants to buy oil in violation of the rules of the oil-for-food program. The program was designed to let Iraq raise money to feed its people from 1996 to 2003 when Saddam Hussein was still in power.
"The trial showed that the charges were groundless," Total lawyer Jean Veil said.
Mr. de Margerie and the other defendants have repeatedly denied any wrongdoing in the case.
Paris prosecutors, who had recommended hitting Total with the maximum possible fine of 750,000 euros ($962,000), have 10 days to decide whether to appeal Monday's ruling.
The oil-for-food program allowed Iraqi authorities to sell about $65 billion worth of crude oil to buy primary goods and mitigate the impact on the Iraqi population of an international embargo and sanctions in place at the time. The proceeds were also used to pay damages to Kuwait following the Iraqi invasion of the country in 1991.
A 2005 review of the program, conducted by an independent panel headed by former Federal Reserve Chairman Paul Volcker, derided management of the program as corrupt and inefficient. The report found that mismanagement and criminality allowed the Hussein regime to wring $10.2 billion out of the system through a combination of smuggling and illicit kickbacks and surcharges.
Write to Geraldine Amiel at geraldine.amiel@dowjones.com
Subscribe to WSJ: http://online.wsj.com?mod=djnwires
(END) Dow Jones Newswires
July 08, 2013 11:35 ET (15:35 GMT)
Copyright (c) 2013 Dow Jones & Company, Inc.
Source: http://www.euroinvestor.com/news/2013/07/08/total-ceo-acquitted-in-iraq-oil-for-food-case/12401587
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(PRWEB) July 08, 2013
The independent authority on web design and development, bestwebdesignagencies.com, has announced Savvy Apps as the fourth best Android development company for the month of July 2013. Each month the top performing Android development companies are put through a meticulous evaluation of their services in order to determine which companies produce the best service for custom Android applications. The rankings are released at the start of the month in order to account for the latest developments and achievements of companies competing in the evaluation process.
Savvy Apps provides effective Android development solutions for businesses looking for the best user experience possible. Their services focus on providing effective mobile solutions for businesses looking to have applications on a variety of mobile applications on platforms including the Apple iPhone and iPad, Android, and Windows Phone 8.
Thousands of mobile application development companies are put through a meticulous evaluation process in order to determine which companies provide the best experience for their users and clients in Android development. Five areas of evaluation are used to benchmark and compare the mobile application development services of competing agencies in areas including development quality, design quality, customer support, speed, and bug testing. The results of the evaluations are used to determine the placement of various agencies within the rankings.
Clients of the top performing Android development companies are contacted in order to obtain their unique opinions and perspectives about the services they have used. The independent research team tests applications developed for clients in order to better understand the project?s goal and what was achieved. Clients often times connect directly with bestwebdesignagencies.com through the online commendations and complaints service while also calling in or emailing.
Savvy Apps has been named the fourth best Android development company due to their excellence during the evaluation process. Their client references expressed their appreciation for the types of applications being developed and the overall value received from the application. Those looking for an enterprise-capable Android development company should consider Savvy Apps.
ABOUT bestwebdesignagencies.com
bestwebdesignagencies.com is an independent research firm with a dedication to providing a list of the best web design companies and web development firms in the industry. Through meticulous research and developed methods for evaluating and ranking companies, bestwebdesignagencies.com has provided customers of web design and development services with a great resource to find a top performing web design company. Evaluations are carried out by a specialized team of researchers who examine thousands of applicants each month. bestwebdesignagencies.com provides their rankings free of charge to companies and individuals searching for a quality web design firm or looking for other design and development services with updates being provided on the first of each month. The website also provides information and resources for those looking to learn more about web design and development services.
To view the rankings of the best Android development companies visit:
http://android-app-development.bwdarankings.com/best-android-developer
Companies interested in applying for the rankings visit:
http://www.bestwebdesignagencies.com/rankings/web-design-agencies/apply-for-ranking
Source: http://www.prweb.com/releases/2013/7/prweb10905018.htm
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LONDON (AP) ? Prominent art collector Charles Saatchi says he is divorcing his celebrity chef wife Nigella Lawson because she did not publicly defend his reputation after images emerged of him grasping the throat of his wife in a posh London restaurant.
Tabloid newspapers last month published photos of the incident, which Saatchi described as a "playful tiff."
The 70-year-old Saatchi was given a police "caution" after admitting assault.
He told Britain's Mail on Sunday newspaper that he is divorcing Lawson because he has "clearly been a disappointment" to her and because he is disappointed she did not defend him after the incident.
Lawson's spokesman declined to comment.
Source: http://news.yahoo.com/saatchi-says-divorcing-nigella-lawson-111344034.html
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CRAFT spells out the motives behind those protests: ?Most importantly, the oil exploration activities are widely perceived in Manipur as ignorant of local ownership structures, which has the potential to exacerbate the competing claims over territory. There are now significant civil society movements against these oil exploration activities, while several non-state armed groups have issued statements on the issue. For example, the KNA?[local armed group: Kuki National Army, MB] declared on 28 January that it would oppose oil exploration activities in the Tamenglong and Churachandpur districts, which it claims are part of its ancestral land.?
The internet is loaded with articles complaining about the drilling in Manipur. E.g. the Committee on the Protection of Natural Resources in Manipur urged the state government to respect the wishes and sentiments of indigenous peoples against oil exploration and also to respect their rights over their land, natural resources and allow them to determine their own future.
It is interesting that oil company Jubilant Energy is based in Amsterdam. So far, Dutch involvement is unknown in The Netherlands. No wonder; Jubilant Energy is based at on the Orlyplein 10 in Amsterdam, an address which houses over three hundred companies. In fact, these companies head quarters are not much more than mail boxes. Often there is no personnel whatsoever; it is only an administrative establishment, based in Amsterdam because of the corporation-friendly Dutch tax climate, which enables companies to evade taxes in the countries where they actually operate. A method widely published during the past months. According to the chamber of commerce of Amsterdam, Jubilant Energy has three entities in one building on Orlyplein 10: Jubilant Energy International B.V., Jubilant Energy (Holding) B.V., and Jubilant Energy N.V..?
For an oil company, Jubilant is small. Between March 2012 and March 2013 it had a sales volume of seven hundred thousand barrels, revenues were a moderate ? 13.8 million. The company mainly operates in India and Australia, although its website shows only the mailbox contact address in the Netherlands. Juridically, Jane's Intelligence Review is right in calling it a Dutch company. This raises the question if the Netherlands has any control over its activities in conflict ridden Manipur. Makes being a tax haven the Netherlands ethical or juridical responsible for Jubilant Energy 's activities?
Martin Broek
reseacher on military affairs and arms trade related issues
Source: http://broekstukken.blogspot.com/2013/07/linked-by-oil-company-jubilant-energy.html
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Jack Bowlby, the nephew of former champion racehorse trainer and novelist Jenny Pitman, was prescribed Roaccutane in December 2011. Photograph: SWNS.com
A coroner has expressed concern at the way a prestigious public school cares for pupils in crisis following the case of a boy who died after taking an acne drug that has been blamed for causing depression.
The parents of 16-year-old Jack Bowlby, who was found with a ligature around his neck, also criticised Cheltenham College for the way it acted after the teenager expressed "very dark thoughts".
Jack, the nephew of former champion racehorse trainer and novelist Jenny Pitman, was discovered dead in his room at the school in Gloucestershire, where he was a boarder, in October last year.
The inquest in Cheltenham heard that he was prescribed Roaccutane in December 2011 by consultant dermatologist James Milne. He was originally told to take two tablets ? a dose of 40mg ? a day and this was upped to three pills in January 2012. Within days Jack was complaining of having "very dark thoughts", the inquest was told. Staff at Cheltenham College did not consult Milne but reduced the dose to one tablet.
According to the Medicines and Healthcare products Regulatory Agency (MHRA), which regulates medicines in the UK, users of Roaccutane ? also known as isotretinoin ? have reported depression, aggravation of existing depression, aggressive tendencies, anxiety, and changes in mood, though it stresses such reports are rare. It says suicide attempts and suicide have been reported very rarely (in one in every 10,000 patients or fewer).
When Jack returned to school in September after the summer break, he told a matron he had not been taking the medication but wanted to start it again. He took his first pill on 11 October. At around 7am the next day, boarders in his college house discovered his body in his bedroom.
Milne told the inquest he had stressed the importance of being contacted if any side effects developed. But he said he was not told that Jack had spoken of dark thoughts, adding: "It is quite disturbing. I was unaware. If I had been informed that he had dark or suicidal thoughts I would have wanted to stop the drug immediately and for him to see a psychiatrist."
The inquest heard that Jack had argued with his parents in September 2012, two weeks before his death ? something that was "out of character". His final text to his mother had read: "That's you and me finished." The evening before he was found dead he had been researching suicide notes online ? though he did not leave one.
Tom Osbourne, deputy assistant coroner for Gloucestershire, recorded an open verdict, saying there was "insufficient evidence" to prove what caused Jack's death. "It may have been an accident, it may have been suicide, it may have been Roaccutane. There is insufficient evidence."
Osbourne said he was concerned at the way Cheltenham College handled cases of children in crisis. He said: "It seems to me, and I was very surprised, there is no specific suicide prevention policy or crisis policy at the school. This is a matter for concern.
"The school is looking after a client group of 11-to-17-year-olds, the age group where a crisis is likely to arise. They have charge of 600 young people, therefore it is essential that they have sufficient policies."
After the inquest Jack's family criticised the way Cheltenham College staff dealt with his dark thoughts. Simon Medland QC, speaking for Jack's , said: "Our only hope is that out of this tragedy some good may come.
"We hope that all schools will take very seriously any such reports. In this case no detailed notes were made on exactly what Jack said."
In a statement, Dr Alex Peterken, headmaster of Cheltenham College, said: "There was, sadly, no way of knowing that Jack was about to die in the way that he did. He could not have been part of a more supportive and close-knit school and boarding family. In January 2012, concerns over Jack's emotional well-being were discussed with the family and his medication subsequently reduced."
Source: http://www.guardian.co.uk/education/2013/jul/05/open-verdict-death-cheltenham-college-pupil
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Source: http://www.facebook.com/ironsky/posts/10152975219840416
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NTT DoCoMo has a heritage of exclusively signing up fictional personalities to hawk its handsets and following the likes of Evangelion, JoJo's Bizarre Adventure and One Piece, it's the turn of not-actually-real pop idol Hatsune Miku. She'll be emblazoned on DoCoMo's Xperia A, on a limited run of 39,000 handsets. Vocaloid's poster girl offers a turquoise theme to the hardware, with a hair decal on the back. While there's no specific word yet on software-based tweaks, a website explaining the collaboration is inviting suggestions for logos, ringtone and wallpaper. The phone will launch in Japan only this September, so we advise overseas Miku fans to get straight to work on that visa application.
Filed under: Cellphones, Mobile, Sony
Via: Engadget Japan
Source: DX39
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You might view your laptop as a nice, neatly contained unit?but there's more bursting out of it than meets the eye. In fact, all of its electrical components create complex magnetic and electric fields that spread far and wide, and this video shows you their reach.
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Jezebel Testicles Have Taste Receptors. Do With That What You Will. | Gawker Video Shows Hawthorne Police Arresting Man, Killing His Dog | io9 Christian Bale confirms he won't play Batman in Justice League | Deadspin Who Wants To Go To Jay Cutler's ?80s-Themed Dance Party?
Source: http://lauren.kinja.com/jezebel-testicles-have-taste-receptors-do-with-that-wh-647141184
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Watch Christina Stephens?a practicing occupational therapist and clinical researcher who lost her foot after a crush injury?build herself a working prosthetic leg out of Lego.
Why did she do it?
Someone in my research lab jokingly suggested I make a prosthetic leg out of legos. The joke's on you?I went home and did it. Please don't do this yourself, I don't want you to fall and get hurt!
Fantastic construction and awesome sense of everything.
Christina has a Facebook page and YouTube channel where she features "informational videos related to healthcare, occupational therapy, prosthetics, manual wheelchairs, medical equipment and more."
Thanks for the tip Chris Pirillo!
Thanks for the headline, Burnthissss!
You're reading Leg Godt, the blog with the latest Lego news and the most awesome Lego models in the web. Follow us on Twitter.
Source: http://lego.gizmodo.com/lego-prosthetic-leg-is-yet-another-proof-of-lego-fans-a-641918255
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Washington Nationals' Bryce Harper celebrates as he crosses home for his solo home run during the first inning of a baseball game against the Milwaukee Brewers at Nationals Park Monday, July 1, 2013, in Washington. This is Harper's first game back after being on the disabled list. (AP Photo/Alex Brandon)
Washington Nationals' Bryce Harper celebrates as he crosses home for his solo home run during the first inning of a baseball game against the Milwaukee Brewers at Nationals Park Monday, July 1, 2013, in Washington. This is Harper's first game back after being on the disabled list. (AP Photo/Alex Brandon)
Washington Nationals Bryce Harper watches his ball clear the fence for a solo homer against Milwaukee Brewers starting pitcher Yovani Gallardo during the first inning of a baseball game at Nationals Park, Monday, July 1, 2013, in Washington. (AP Photo/Pablo Martinez Monsivais)
Washington Nationals Bryce Harper acknowledges the fans after his solo home run during the first inning of a baseball game against the Milwaukee Brewers at Nationals Park Monday, July 1, 2013, in Washington. This is Harper's first game back after being on the disabled list. (AP Photo/Alex Brandon)
Washington Nationals Bryce Harper is greeted at dugout by teammates after hitting a solo homer against the Milwaukee Brewers starting pitcher Yovani Gallardo in the first inning of a baseball game at Nationals Park, Monday, July 1, 2013, in Washington. (AP Photo/Pablo Martinez Monsivais)
Washington Nationals Bryce Harper connects for a solo homer against Milwaukee Brewers starting pitcher Yovani Gallardo during the first inning of a baseball game at Nationals Park, Monday, July 1, 2013, in Washington. (AP Photo/Pablo Martinez Monsivais)
WASHINGTON (AP) ? On his first swing back from a knee injury, Bryce Harper hit a curtain-call home run.
Welcome back, slugger.
"Typical Bryce right there, he's all about the drama," teammate Jayson Werth said. "He didn't disappoint us, I guess."
Harper's first-inning solo shot Monday night was the sparkplug for the Washington Nationals in a 10-5 pounding of the slumping Milwaukee Brewers.
It was the 20-year-old Harper's only hit of the night, but the domino effect was real. Werth, unhappily bumped to second in the lineup because of Harper's return, got five RBIs. Starting pitcher Jordan Zimmerman was an unexpected offensive juggernaut with a team-high three hits, including a double to start a five-run third inning and a single to open a two-run fourth.
Put it all together and the Nationals had their second runaway win in as many days. After toying with .500 for the entire month of June, Washington moved two games above the break-even mark for the first time since late May.
"It's kind of contagious. Everybody knows we've got some work to do," Washington manager Davey Johnson said. "Let's get down to business. Let's get serious."
Harper missed 31 games with bursitis in his left knee ? the most lingering fallout from his collision with the Dodger Stadium wall ? and was activated from the 15-day disabled list before the game. Batting third and playing left field, he launched the second pitch he saw, a fastball from Yovani Gallardo (6-8), into the visitors' bullpen beyond left field for an opposite-field homer.
Harper raised his right arm and pointed to the fans as he finished his familiar sprint around the bases. After lots of high-fives in the dugout, he returned to the top of the steps and gave a thumbs-up curtain call.
"I felt like I was back on opening day," said Harper, who homered in his first two at-bats of the season. "I was trying to get something I could drive. I got a pitch I could handle a little bit and put it where I wanted to."
The solo shot was Harper's 13th homer of the season and 24th RBI. He hurt his knee in the mishap in Los Angeles on May 13 and reinjured it several times over the following two weeks before going on the disabled list. He went 4 for 11 in minor league rehab games last week.
He finished 1 for 4 with a walk on Monday. He slid hard into second base on a double play in the sixth inning, showing no signs of being gimpy in his knee.
The Nationals improved to 26-19 when Harper plays; they are 16-21 when he doesn't. He and the teammates made life easy for Zimmermann (12-3), who had an 8-0 lead at one point and pitched six innings. He allowed four runs and tied unbeaten Max Scherzer of the Detroit Tigers for the major league lead in wins.
Zimmermann said his night at the plate was better than his night on the mound. He joked about the size of his bat, initially claiming it was 39 inches instead of 34.
"I pitch all right," Zimmerman said. "But definitely three hits is awesome."
Werth's mood, by contrast, was nowhere near jovial, especially for a player with his best RBI game since 2009. He kept reporters waiting for nearly an hour after the game and proclaimed himself "just a grunt out here playing ball."
"I don't necessarily like hitting second," Werth said. "But if that's the best for our team, I've said it before: Last year when I led off, it wasn't personally the best fit for me, but it was the best for our team and that's why I felt like it should have happened. And the same goes for me hitting second now."
The Nationals, perhaps finally finding their stride after a middling first half of the season, have won five of seven to pull within six games of the first-place Atlanta Braves in the NL East. Washington scored a season-high 13 runs on Sunday against the New York Mets.
Meanwhile, the Brewers, missing injured slugger Ryan Braun, have lost six straight and are 32-49 at the midpoint of their season.
Gallardo struggled for the second straight start. With the Brewers' bullpen spent after Sunday's 14-inning loss to Pittsburgh, the right-hander was left to fend for himself until he was pulled in the fourth inning. He allowed eight runs, and his ERA rose from 4.20 to 4.78.
"You don't expect to see it from Yovani because he's been so consistent through his career, but he's at a point right now where for some reason he's deep in counts to almost every batter," Milwaukee manager Ron Roenicke said. "We're 3-2 and he's having to make a great pitch, and you can't survive if you keep doing that."
NOTES: Johnson said LHP Ross Detwiler had a good bullpen session and is on pace to start Wednesday as scheduled. Detwiler had stiffness in his lower back after his last start. ... The Nationals optioned RHP Erik Davis to Triple-A Syracuse to make room for Harper. ... Brewers RHP Kyle Lohse will make his next start Wednesday on two days rest. Lohse started Sunday, but he went only 1 2-3 innings before a 2-hour rain delay.
___
Follow Joseph White on Twitter: http://twitter.com/JGWhiteAP
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July 1, 2013 ? There's not much difference between what makes a man and what makes his beer -- at least at the molecular level -- according to a new study led by Professor John Schwabe at the University of Leicester.
Scientists used a powerful technique called protein crystallography to look at 3D structures of protein complexes purified from cultured human cells. They discovered that a family of complexes, that switch off gene expression, is regulated by small signalling molecules called inositol phosphates.
This latest study shows that this mode of regulation is conserved from yeast right through to man and is a fundamental process for life.
This discovery is potentially important for developing anti-cancer drugs since these complexes are emerging as effective cancer treatment targets.
The research was funded by the Wellcome Trust and involved collaboration with scientists from the University of Oxford. It was published online ahead of print (July 11) in the journal Molecular Cell.
The importance of this work is emphasised by the award, in November 2012, of ?2.4 million in the form of a "Wellcome Trust Senior Investigator Award" to Professor John Schwabe to continue and develop this area of research.
Professor Schwabe said: "Gene regulation is an essential biological process that occurs in every cell in the body to control which proteins are expressed in particular tissues. We have been studying enzymes called Histone Deacetylases (HDACs) that regulate this process. The action of HDACs causes the DNA to become more tightly packaged and thus switches off genes by making them unavailable for expression. HDACs are recruited to DNA by a number of accessory proteins (corepressors) that target the enzyme to the correct gene."
In 2012, the research team announced in Nature that they had discovered a completely new and unexpected mechanism through which one particular HDAC complex (HDAC3 bound to its companion protein SMRT) is regulated.
Professor Schwabe said: "We wanted to ask whether this mode of regulation might apply to other HDAC complexes and be a general principle for HDAC regulation. Now we have taken this investigation several steps forward.
"We have solved the first structure of HDAC1 bound to one of its corepressor proteins (MTA1 -- Metastasis-associated protein 1). This new structure allows us to examine how the proteins interact at the atomic level and reveals molecular details that have allowed us to probe the interaction surface.
"We have identified that there is an inositol phosphate-binding site at the interface between the two proteins, and through functional studies, we have confirmed that inositol phosphates are key regulators throughout this class of enzyme.
"This establishes that inositol phosphate regulation is a general paradigm that is conserved from yeast to man. In addition, we have shown that two MTA1 molecules come together to recruit two HDAC enzymes, and we suggest that MTA1 is critical for recruiting HDAC1 to DNA."
Professor Schwabe also emphasised that his research team is very privileged to have secured further funding from the Wellcome Trust to support this programme of research for the next 7 years: "We expect to gain an in depth insight into the role of inositol phosphates in the regulation of class I histone deacetylases and the specificity conferred to histone deacetylases by their recruitment into large multi protein complexes."
The research team used a cutting edge technique (protein crystallography) to look at the 3D structure of proteins involved in gene regulation. They optimised the conditions needed to grow microcrystals and took these to the UK's powerful synchrotron (Diamond Light Source, Oxford) to obtain diffraction data. These data are used to build images of the proteins, and for the first time, the team has been able analyse how the proteins interact with each other.
"With this new level of molecular detail we are exploring the design of novel HDAC inhibitors to target of the HDAC-corepressor interface. These may provide the foundation for future drug development and may lead to new anti-cancer therapies."
Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/SvXNBM-GhfI/130701135438.htm
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PRESCOTT, Ariz. (AP) ? Nineteen members of the Granite Mountain Hotshots, based in Prescott, Ariz., were killed Sunday when a windblown wildfire overcame them north of Phoenix. It was the deadliest single day for U.S. firefighters since Sept. 11. Fourteen of the victims were in their 20s. Here are the stories of those who died:
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ANDREW ASHCRAFT: AN ATHLETIC, GO-GETTER
Prescott High School physical education teacher and coach Lou Beneitone taught many of the Hotshots, and remembered Andrew Ashcraft, 29, as a fitness-oriented student.
"He had some athletic ability in him and he was a go-getter, too. You could pretty much see, from young freshman all the way, he was going to be physically active."
Beneitone said athletic prowess was a must for the Hotshots. "That's what it takes. You gotta be very physically fit, and you gotta like it, gotta like the hard work."
Ashcraft, a member of The Church of Jesus Christ of Latter-day Saints, was honored to be a member of the Hotshot crew, and "he just had a really sweet spirit about him," Elise Smith, a Prescott resident, told The Deseret News of Salt Lake City.
Ashcraft left behind a wife, Juliann, and four children, the newspaper reported.
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ROBERT CALDWELL: THE SMART ONE
Friends characterized Robert Caldwell, 23, as the smart man in the bunch.
"He was really smart, he had a good sense of humor," said Chase Madrid, worked as a Hotshot for two years, but sat this year out.
"He was one of the smart guys in the crew who could get the weather, figure out the mathematics. It was just natural for him," Madrid said.
It was Caldwell's intelligence and know-how that got him appointed as a squad boss.
His cousin, Grant McKee, was also a Hotshots member and also was killed on Sunday.
"Robert was a gentle giant ? he was man of few words," said his aunt, Laurie McKee.
He had just gotten married in November, and had a 5-year-old stepson.
"Both of these boys were only interested in having a family life. Robert was newly married, and Grant was engaged. They just wanted the house and the dog," she said.
Mary Hoffmann was grandmother to both boys.
"To have two grandson's gone, it's devastation," she said.
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TRAVIS CARTER: STRONG AND HUMBLE
At Captain Crossfit, a gym near the firehouse where the Hotshots were stationed, Travis Carter was known as the strongest one out of the crew ? but also the most humble.
"No one could beat him," trainer Janine Pereira said. "But the thing about him, was he would never brag about it. He would just kill everyone and then go and start helping someone else finish."
Carter, 31, was famous for once holding a plank for 45 minutes, and he was notorious for making up brutal workouts.
The crew recently did a five-mile run during wilderness training, then he made them go to Captain Crossfit in the afternoon for another really hard workout.
"The other guys who came in here always said that even though he was in charge, he was always the first one at the fire, the first one in action," Pereira said.
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DUSTIN DEFORD: DRY SENSE OF HUMOR
Dustin DeFord, 24, had been a firefighter since he turned 18 and started as a volunteer in tiny Ekalaka, Mont. His father, the Rev. Steve DeFord, said the outpouring of support there has been unbelievable.
"We've got enough food in the house to last a year," he said.
DeFord graduated from Cornerstone Bible Institute in Hot Springs, S.D., three years ago, his father said, and always believed God was his guiding force.
On his Facebook page last year, he talked about wanting to find work in western Montana, but God instead moved him to Arizona. Immediately he worked to improve his skills on the climbing wall at a gym near the firehouse.
"He listened very well. He was very respectful," said Tony Burris, a trainer at Captain Crossfit. "He kind of had a dry sense of humor."
Another trainer, Janine Pereira, echoed that sentiment.
"You would say something to him, and he would respond with a crack, which was funny because he was so shy," she said.
DeFord is survived by nine brothers and sisters, including a Marine Corps staff sergeant who is traveling home from Afghanistan, an older brother who is fighting fire with a helicopter team in New Mexico and a younger brother on a Hotshot crew in Alaska.
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CHRIS MACKENZIE: 'JUST LIKE HIS DAD'
An avid snowboarder, Chris MacKenzie, 30, grew up in California's San Jacinto Valley, where he was a 2001 graduate of Hemet High School and a former member of the town's fire department. He joined the U.S. Forest Service in 2004 then transferred two years ago to the Prescott Fire Department, longtime friend Dav Fulford-Brown told The Riverside Press-Enterprise.
MacKenzie, like at least one other member of the Granite Mountain Hotshots, had followed his father into firefighting. Michael MacKenzie, a former Moreno Valley Fire Department captain, confirmed that he had been informed of his son's death.
"I can't talk about it," he said.
Fulford-Brown, also a former firefighter, feared for the worst as soon as he heard the news of the Arizona firefighters. "I said, 'Oh my God, that's Chris' crew.' I started calling him and calling him and got no answer," he told The Press-Enterprise. MacKenzie, he said, "lived life to the fullest ... and was fighting fire just like his dad."
"He was finishing his credentials to get promoted and loved the people. It's an insane tragedy."
___
ERIC MARSH: HOOKED ON FIREFIGHTING
Eric Marsh, 43, was an avid mountain biker who grew up in Ashe County, N.C., but became hooked on firefighting while studying biology at Arizona State University, said Leanna Racquer, the ex-wife of his cousin. Marsh lived with Racquer and her then-husband during the winters from 1992 through 1996 in North Carolina, but kept returning to Arizona during fire season.
After college, he kept working as a firefighter, eventually landing a full-time job and settling in northern Arizona. He even moved his parents to the state, she said. Marsh was superintendent of the Hotshot crew and the oldest of the 19 who died.
"He's was great ? he was the best at what he did," Racquer said. "He is awesome and well-loved and they are hurting," she said of his family.
Marsh was married but had no children, said his cousin, Scott Marsh, of Pisgah Forest, N.C. His father, John Marsh, told the Jefferson Post newspaper in Jefferson, N.C., that his only child "was a great son."
"He was compassionate and caring about his crew."
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GRANT MCKEE: GIVING NATURE
Grant McKee, 21, loved to give things away.
"Even as a child, I'd ask him where things were, and he'd say, 'Oh such and such liked it.' And sometimes it really cost a lot! But he'd say, 'Oh he liked it so much,'" said his grandmother, Mary Hoffmann.
"So on his birthday, I started to say, 'I hope you're going to keep this!'" she said.
McKee's cousin, Robert Caldwell, also was a Hotshot and also was killed on Sunday.
"I had four grandchildren, but Grant was the sweetest most giving nature of any of my grandkids," Hoffman said. "We used to think he was a little angel."
McKee's mother said Grant was training to be an emergency medical technician and only intended to work with the Hotshots for the summer.
During EMT training, he would ask for extra shifts at the emergency room. And because his superiors liked him, they would give them to him, Laurie McKee said.
"Grant was one of the most likable people you could ever meet," she said. "Grant was friendly, he was outgoing. Everybody loved Grant."
___
SEAN MISNER: 'TREMENDOUS HEART AND DESIRE'
Sean Misner, 26, leaves behind a wife who is seven months pregnant, said Mark Swanitz, principal of Santa Ynez Valley Union High School in Santa Barbara County, where Misner graduated in 2005.
Misner played varsity football and also participated in the school's sports medicine program where he wrapped sprained ankles and took care of sidelined athletes.
"He was a team player, a real helper," Swanitz told The Associated Press.
In high school, Misner played several positions, including wide receiver and defensive back. He was slim for a high school football player, but that didn't stop him from tackling his opponents, recalled retired football coach Ken Gruendyke.
"He played with tremendous heart and desire," Gruendyke said. "He wasn't the biggest or fastest guy on the team but he played with great emotion and intensity."
___
SCOTT NORRIS: THE 'IDEAL AMERICAN GENTELMAN'
Scott Norris, 28, was known around Prescott through his part-time job at Bucky O'Neill Guns.
"Here in Arizona the gun shops are a lot like barbershops. Sometimes you don't go in there to buy anything at all, you just go to talk," said resident William O'Hara. "I never heard a dirty word out of the guy. He was the kind of guy who if he dated your daughter, you'd be OK with it.
"He was just a model of a young, ideal American gentleman."
O'Hara's son Ryan, 19, said Norris' life and tragic death had inspired him to live a more meaningful life.
"He was a loving guy. He loved life. And I've been guilty of not looking as happy as I should, and letting things get to me, and Scott wasn't like that at all."
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WADE PARKER: ANOTHER SECOND GENERATION FIREFIGHTER
At 22, Wade Parker had just joined the Hotshots team. His father works for the nearby Chino Valley Fire Department, said retired Prescott Fire Department Capt. Jeff Knotek, who had known Wade since he was "just a little guy."
The younger Parker had been very excited about being part of the Hotshot crew, Knotek said.
"He was another guy who wanted to be a second generation firefighter," Knotek said. "Big, athletic kid who loved it, aggressive, assertive and in great shape."
"It's just a shame to see this happen," Knotek said.
___
JOHN PERCIN JR.: STRONG, BRAVE, AMAZING
He loved baseball and had an unforgettable laugh. In his aunt's eyes, John Percin Jr. was, simply, "an amazing young man."
"He was probably the strongest and bravest young man I have ever met in my life," Donna Percin Pederson said in an interview with The Associated Press from her home in Portland, Ore.
John Percin Sr. declined to comment Monday. "It's not a good time right now."
Percin, 24, was a multisport high school athlete who graduated in 2007 from West Linn High School, southeast of Portland.
Geoff McEvers grew up playing baseball with Percin and remembered him as a fun-loving guy with an unforgettable laugh, The Oregonian newspaper reported.
McEvers said he learned about the Percin's death through friends.
"It's already tragic when you hear about those who died," McEvers told the newspaper, "but when you find out it's someone you know personally, it's tough."
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ANTHONY ROSE: 'BLOSSOMED' AS FIREMAN
Anthony Rose, 23, was one of the youngest victims. He grew up in Wisconsin and previously worked as a firefighter in nearby Crown King before moving on to become a Hotshot.
Retired Crown King firefighter Greg Flores said Rose "just blossomed in the fire department. He did so well and helped so much in Crown King. We were all so very proud of him."
Flores said the town was planning a fundraiser for Rose and hoped to also have a memorial to honor him.
"He was the kind of guy that his smile lit up the whole room and everyone would just rally around him," he said. "He loved what he was doing, and that brings me some peace of heart."
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JESSE STEED: 'GREAT FOR MORALE'
Jesse Steed's former colleagues remember him as a joker.
"He was a character. If you look at all the old photos of him, he was doing things to make people laugh," said Cooper Carr, who worked with Steed in the Hotshots from 2001 to 2003.
"He was good at impressions, and he sang songs; he was just great for morale. He'd just talk in a funny voice and have us all in stiches," Carr said. "And he was strong as an ox."
Carr remembers that Steed once spent the better part of an hour positioning a water bottle just right for a photo so that it would look like Yosemite Falls was cascading into it.
Steed was also remembered for his dedication to fighting wildfires.
"He did it for a long, long time. I think he started in 2001, when he got out of the Marines. A job like the Hotshots is hard, hard work, and you don't stay in it if you don't love it," Carr said.
Steed, 36, was one of the older members of the crew. Renton, Wash., police officer Cassidy Steed said his brother "always put his life on the line for people who he knew he would never meet."
___
JOE THURSTON: DARING AND DETERMINED
Back home in Cedar City, Utah, Joe Thurston, 32, used to go to an area reservoir with friends and promptly show how fearless he could be.
"He was definitely one of the daredevil types," longtime friend Scott Goodrich told the Salt Lake Tribune. "We went to Quail (Creek) Reservoir, and we'd be finding 40- to 50-foot cliffs that people would be scared to jump off. He would just show up and be front-flipping off of them."
He brought this bold streak to the Granite Mountain Hotshots.
"He had all the qualities that a firefighter would need to possess," E.J. Overson, another friend, told the Salt Lake City newspaper. "He was service-oriented, very caring and willing to do some things that many others would say, 'I don't want to get involved.'"
Thurston was also determined, generous and hardworking, his friends said.
He went to Cedar High School and Southern Utah University, played in a band and rode skateboards.
"He was one of the best guys I ever met," Goodrich said.
___
TRAVIS TURBYFILL: 'BIG, HUGE MARINE'
Known as "Turby" among crew members, Travis Turbyfill got a full-time position with the Hotshots when another member's girlfriend asked him to quit.
Turbyfill, 27, often worked with other Hotshots at Captain Crossfit, a warehouse filled with mats, obstacle courses, climbing walls and acrobatic rings near the firehouse. He would train in the morning and then return in the afternoon with his wife and kids.
Trainer Janine Pereira said she recently kidded Turbyfill for skipping workouts. His excuse was that he wanted to spend some quality time at Dairy Queen.
"He was telling me that it's because it was Blizzard week, and he was just going to eat a Blizzard every night," she said.
Tony Burris, another trainer, said he enjoyed watching Turby with his two daughters.
"Because he's this big, huge Marine, Hotshot guy, and he has two little girls, reddish, blonde curly hair, and they just loved their dad," he said.
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BILLY WARNEKE: 'DOING WHAT HE LOVED'
Billy Warneke, 25, and his wife, Roxanne, were expecting their first child in December, his grandmother, Nancy Warneke, told The Press-Enterprise newspaper in Riverside, Calif. Warneke grew up in Hemet, Calif., along with his fellow Granite Mountain hotshot, Chris MacKenzie. He was a four-year Marine Corps veteran who served a tour in Iraq and had joined the hotshot crew in April, buying a property in Prescott, near where his sister lived, the newspaper reported.
Nancy Warneke said she called her sister after seeing the fire on the news.
"She said, 'He's gone. They're all gone,'" Nancy Warneke told The Press-Enterprise. "Even though it's a tragedy for the whole family, he was doing what he loved to do. He loved nature and was helping preserve nature."
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CLAYTON WHITTED: HE'D 'LIGHT IT UP'
Full of heart and determination, Clayton Whitted, 28, might not have been the biggest guy around, but he was among the hardest-working. His former Prescott High School coach, Lou Beneitone, said Whitted was a "wonderful kid" who always had a big smile on his face. Whitted played for the football team as an offensive and defensive lineman.
"He was a smart young man with a great personality, just a wonderful personality," said Beneitone. "When he walked into a room, he could really light it up."
Beneitone said Whitted loved being a firefighter and was well-respected among his crew. He says he ran into Whitted about two months ago and they shook hands and hugged, and talked about the upcoming fire season.
"I told him to be careful," Beneitone said.
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KEVIN WOYJECK: FOLLOWING IN HIS FATHER'S FOOTSTEPS
For Kevin Woyjeck, 21, the fire station was always a second home. His father, Capt. Joe Woyjeck, is a nearly 30-year veteran of the Los Angeles County Fire Department. Keith Mora, an inspector with that agency, said Kevin often accompanied his dad to the station and on ride-alongs and always intended to follow in his footsteps.
"He wanted to become a firefighter like his dad and hopefully work hand in hand," Mora said Monday outside of the fire station in Seal Beach, Calif., where the Woyjeck family lives.
Mora remembered the younger Woyjeck as a "joy to be around," a man who always had a smile on his face. He had been trained as an EMT and worked as an Explorer, which is a mentorship training program to become a professional firefighter.
"He was a great kid. Unbelievable sense of humor, work ethic that was not parallel to many kids I've seen at that age. He wanted to work very hard."
As he spoke, Mora stood before an American flag that had been lowered to half-staff. His own fire badge was covered with a black elastic band, a show of respect and mourning for those lost in the line of duty.
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GARRET ZUPPIGER: A RED BEARD, AND A SENSE OF HUMOR
Garret Zuppiger, 27, loved to be funny, said Tony Burris, a trainer at a gym where many of the Hotshots worked out.
Burris said the two bonded over their hyper-manly ginger facial hair.
"We both had a red beard and so we would always admire each other's beards," he said. "We also had a few conversations about beer."
Zuppiger's humor was evident on his blog where he wrote about his grandmother's one-eyed Chihuahua, his "best hair day ever" and a hike with his mother on Camelback Mountain in Phoenix. There's also photos of a tongue-in-cheek project to build a "ski-chair," in which a living room recliner was placed atop two skis.
"Garret Zuppiger turns 25!" he wrote in a post several years ago. "Everyday is like a gift!!"
___
Associated Press reporters Raquel Maria Dillon in Seal Beach, Calif., Sue Manning in Los Angeles; and Felicia Fonseca and Hannah Dreier in Prescott contributed to this story.
Source: http://news.yahoo.com/hotshots-killed-ariz-fire-remembered-mourned-220253670.html
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The 'Kiss You' group have come under fire from the anti-gay religious group, who have previously described Taylor Swift as a "whore", the Huffington Post reports.
They announced that they will picket the group's July 19 concert in Kansas City.
One Direction were described as "a perfect representation of this filthy world and the sin-chasing, fag-enabling, God-hating, Christ-rejecting UK" by the protesters.
They continued: "These freaks and their fans think it's funny for these five perverts to grab each other's asses on stage. They glamorise sin and make a mock of God's standards."
The Church also parodied the band's hit 'Kiss You' by replacing the lyrics with words about obeying God's orders.
The Vaccines told Digital Spy today (June 30) that One Direction are "more creative" than they are given credit for.
Justin Young said: "They're really nice guys and more creative than many people would probably believe."
Watch One Direction's music video for 'One Way or Another (Teenage Kicks) below:
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